منابع مشابه
Functionalization of α-synuclein fibrils
The propensity of peptides and proteins to form self-assembled structures has very promising applications in the development of novel nanomaterials. Under certain conditions, amyloid protein α-synuclein forms well-ordered structures - fibrils, which have proven to be valuable building blocks for bionanotechnological approaches. Herein we demonstrate the functionalization of fibrils formed by a ...
متن کاملProteasome impairment by α-synuclein
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide and characterized by the loss of dopaminergic neurons in the patients' midbrains. Both the presence of the protein α-synuclein in intracellular protein aggregates in surviving neurons and the genetic linking of the α-synuclein encoding gene point towards a major role of α-synuclein in PD etiology. The exa...
متن کاملBioinformatics Analysis of α-Synuclein
Authors of papers to the bioinformatics approach tbo analyse the nucleotide and amino acid sequence of alpha synuclein nucleotide and amino acid. including as the character of physical and hydrophobicity, seondary structure prediction domains, prediction of the conserved domains and phylogenetic analysis. The results showed the α-synuclein encode a deduced 1462amino acid, had a predicted molecu...
متن کاملThe Function of α-Synuclein
Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all patients with PD suggests a central role for this protein in the sporadic disorder. Indeed, the accumulation of misfolded α-synuclein now defines multiple forms of neural degeneration. Like many of the proteins that ...
متن کاملα-Synuclein as a ferrireductase.
Many proteins associated with neurodegenerative diseases have poorly defined or unknown functions. α-Synuclein is one such protein which is associated with a range of diseases including Parkinson's disease. Now accepted as a metal-binding protein, α-synuclein's function could possibly be defined in relation to the binding of cofactors. It has been suggested recently that α-synuclein is able to ...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2012
ISSN: 1554-8627,1554-8635
DOI: 10.4161/auto.19085